Pilot study: Kleinsche Fields increase cells energy production
Mitochondria, the "power plants" of our cells, are essential for optimal cell function and for keeping the body healthy. In her pilot study, Prof. Dr. Brigitte König investigated precisely these small cell organelles by asking the question: Do Kleinsche Fields have an influence on cellular energy production, regeneration and oxidative stress resistance of cells?
The in-vivo, ex-vivo and in-vitro pilot study aimed to quantify possible effects of Kleinsche Fields technology on mitochondrial processes and various clinical markers of peripheral blood leukocytes (PBMC). Five subjects with various pre-existing conditions (including diabetes, hypertension, polyneuropathy, sleep disorders) used a BioRelax mattress topper with Kleinsche Fields technology for a period of three months. During this time, no lifestyle changes were made in order to exclude external influences.
Interesting facts
The following parameters were investigated in the pilot study to determine the influence of Kleinsche Fields technology on mitochondrial functions:
- the ratio of mitochondrial to nuclear DNA (mtDNA/ntDNA)
- the mitochondrial mass
- ATP production (energy production)
- the mutation rate of mitochondrial DNA (ΔmtDNA4977)
- PGC-1α expression (new synthesis)
In addition, the cell response to oxidative stress was tested using an H₂O₂ test.
The pilot study was carried out with peripheral blood leukocytes (PBMC). It has been shown in numerous publications that the mitochondrial function and mitochondrial biogenesis of PBMC are altered in various "diseases of civilization" such as diabetes, metabolic syndrome, neurodegenerative diseases (Alzheimer's, Parkinson's), allergies, but also in skin diseases such as vitiligo or fibromyalgia and are therefore suitable as relevant target cells for investigations.
in-vitro pilot study
More "cell power plants" detectable
Increase in the number of mitochondria
The results show a significant increase in the number of mitochondria in the cells, which could be detected using three different measured variables. These included a significant increase in mitochondrial mass, which increased 8-fold on average.
More mitochondria per cell
More mitochondria per cell The ratio of mitochondrial DNA to nuclear DNA increased significantly after 3 months of monotherapy with Kleinsche Fields - on average 9.96-fold (from 222.03 to 2212.08 copies per nuclear DNA). This means that the number of "cell power plants" increased independently of cell division and is an important indication of improved mitochondrial regeneration.
Increased new formation
In the course of the application of Kleinsche Fields technology, there was a significant increase in basal PGC-1-alpha expression. This marker is primarily associated with the formation of new mitochondria and indicates improved mitochondrial biogenesis.
Increased regeneration of the "cell power plants"
Reduction of damaged mitochondria
The mutation ΔmtDNA4977, a marker for damaged mitochondria, was detectable in three out of five test subjects. This mutation was significantly reduced in all three. In one subject, the mitochondrial mutation was no longer detectable after 12 weeks. The study shows that not only can more mitochondria be formed using Kleinsche Fields technology, but the "cellular power plants" can also regenerate and reorganize themselves better.
Case example
40-year-old female test subject with hardened venous conglomerates and "heavy" legs
The hardened venous conglomerates (dark blue) of an overweight test person (BMI: 27) with "heavy" legs and spider veins were recorded using before and after documentation. The documentation of the surface veins after 3 months of mono use of the BioRelax mattress topper shows that
- the venous conglomerates are softer
- the feeling of "heavy" legs is clearly less noticeable for the test person
ATP generation increases
"Cell power plants" produce more energy
Whether mitochondria are really efficient can only be seen in the production of the energy carrier ATP (adenosine triphosphate) - regardless of the number of mitochondria. Using Kleinsche Fields technology, ATP production in the mitochondria increased on average from 70.23% to 99.58%. This indicates that Kleinsche Fields can improve energy production in the cells.
Increased resistance to stressors
Mitochondria show
higher performance
Weakened and damaged mitochondria cannot maintain their energy production under "stress". This makes stress resistance another important factor when assessing the performance of cellular power plants. ATP production increased by 105.4% on average after oxidative stress (H₂O₂ stimulation). This indicates improved stress resistance and higher mitochondrial performance.
Case example
82-year-old female test subject with renal artery stenosis
There was a relevant improvement in the classic clinical-chemical parameters in a test person with post-chemo polyneuropathy in her fingers, feet and legs (chemotherapy 5 years ago), melancholic-depressive disorder and renal artery stenosis with creatinine elevation. After 3 months of mono use of the BioRelax mattress topper:
- the creatinine value improved significantly
The test person also reported that the symptoms of post-chemo polyneuropathy had completely disappeared.
Individual clinical improvements were also documented:
- One diabetic achieved normoglycemia.
- One subject with high blood pressure was able to reduce his values from 180/120 mmHg to 140/80 mmHg.
- In one diabetic with a wound healing disorder, the wound closed and the pain was reduced.
- Complaints due to polyneuropathy were significantly reduced in one test person.
- Four out of five test subjects reported better sleep, less pain and a more stable circulatory function.
Results of the pilot study at a glance
The pilot study indicates that Kleinsche Fields can have a positive influence on mitochondrial functions. The increased mitochondrial mass, improved ATP production and reduced damage to the cellular powerhouses suggest that Kleinsche Fields could optimise cellular regeneration and energy provision.
It is particularly notable that these effects were achieved without additional medical interventions or lifestyle changes. Further large-scale studies are needed to validate these results.
Is the pilot study relevant to everyday life?
Our conclusion of the pilot study
Because mitochondria play a central role in chronic diseases, cell ageing and metabolic disorders, the use of the Kleinsche Fields technology could be a promising approach for regeneration, prevention and therapy:
The results suggest that Kleinsche Fields could promote the flow rate of the blood in the smallest blood vessels, the microcirculation. This improves the transport of oxygen and nutrients to the cells as well as the removal of metabolic end products.
The pilot study provides initial indications that Kleinsche Fields could support the natural regeneration of cells. This could help to improve energy, sleep and general wellbeing.
The results indicate that Kleinsche Fields could have a preventive effect, among others in type II diabetes, metabolic syndrome, cardiovascular dysfunction (circulatory disorders), neurodegenerative diseases as well as sleep disorders and abnormal pain sensations.