Experimental study:
More cell energy through Kleinsche Fields
In his experimental study, Jonas Heisterkamp from Otto von Guericke University Magdeburg investigated the question of whether Kleinsche Fields can increase the energy production of cells. To this end, he investigated the mitochondria - the "power plants" of cells - and used a cell model for human immune cells under the supervision of Prof. Dr. Brigitte König.
Using Kleinsche Fields, the mitochondrial activity was measured using the Bioenergetic Health Index (BHI) over different time periods (1h, 4h, 8h, 24h). This allowed the researcher to investigate the effect of Kleinsche Fields on the mitochondrial bioenergetics of immune cells.
Interesting facts
The mitochondria were examined using the Bioenergetic Health Index (BHI). This involves the use of chemical modulators that influence the respiratory chain. The measurements included
- the oxygen consumption rate (OCR, mitochondrial metabolism)
- ATP production
- maximum respiration
- the reserve respiratory capacity
- the proton leak
The Bioenergetic Health Index provides information about the health status of mitochondria. This assessment of mitochondrial bioenergetics can be used as a kind of early warning system for the body, as many diseases are associated with mitochondrial dysfunction and inflammatory processes in cells of the immune system have an increased energy requirement. The BHI therefore represents a biomarker that can provide information about possible complaints or diseases by determining the metabolic potential of the cells via their mitochondria.
The target cells used in the study were THP-1 cells, which serve as a model for human immune cells, both as suspension and PMA-differentiated cells.
as cell model
Kleinsche Fields
Improved performance of the "cell power plants"
Increased activity of the mitochondria
The results show that increased mitochondrial respiration and ATP production were measurable after just 1 hour of stimulation. Cell energy production (ATP) increased by 58 % within the first hour. These results indicate that Kleinsche Fields can improve mitochondrial performance.
Mitochondria work more efficiently
Maximum respiration increased by 227 % and reserve respiratorycapacity by 448 %. For both parameters, the higher the better.
Stabilization of cell activity
After 24 hours, cell activity stabilized at a stable level, which indicates a long-term adaptation and regulation of the mitochondria.
Indication of the regulatory effect of the Kleinsche Fields
Long-term adaptation of the mitochondria
After 4 hours of stimulation, the values for reserve respiratory capacity and ATP production decreased slightly, indicating metabolic adaptation. After 8 hours of stimulation, the values stabilized, and after 24 hours a BHI of 1.51 was measured, suggesting a long-term regulation of cellular energy processes.
Measuring mitochondrial function with the BHI
What do maximum respiration & co. mean?
The Bioenergetic Health Index (BHI) helps to identify mitochondrial dysfunctions, which are often associated with chronic diseases or energy problems. The index is based on several parameters, including:
- Basal respiration: oxygen consumption for the basic cell functions. It shows the current baseline state of the energy supply of the cells and is therefore a measure of the amount of energy needed to maintain the basic functions.
- ATP production: the efficiency of energy generation. ATP, short for adenosine triphosphate, is the universal energy currency in cells and serves as an energy store and energy carrier. It is a measure of the effectiveness of the mitochondria.
- Proton leak: energy losses through leaks in the mitochondrial membrane.
- Maximal respiration: the maximum oxygen consumption rate. It indicates the maximum possible output that the cellular powerhouses can deliver under their current metabolism. A low maximal respiration can indicate that the number of mitochondria is reduced or that there is damage to the inner mitochondrial membrane or to components of the respiratory chain. The following therefore applies: the greater the maximal respiration, the better.
- Reserve respiratory capacity: the ability of the cells to respond to additional energy demands. If demand exceeds the available energy (for example through an increase in physical activity), the cell can draw on the reserve respiratory capacity of the mitochondria. This ensures the supply and normally prevents an “energy crisis”. The same applies here: the greater the reserve capacity, the better.
- Non-mitochondrial respiration: processes that consume oxygen outside the mitochondria.
PMA-differentiated cells react differently
Visible differences between the cell types
PMA-differentiated cells responded to Kleinsche Fields with higher ATP production (+30 % after 1 hour). Further research is needed to be able to make more precise statements. After 24 hours of stimulation, however, mitochondrial respiration decreased, which also indicates an adaptation to the magnetic field.
Results of the study at a glance
The results show that Kleinsche Fields can increase cell energy production and lead to long-term adaptation of the mitochondria. Together with the greatly increased maximum respiration, this results in a high reserve respiratory capacity, which leads to the conclusion that the maximum possible energy production of the mitochondria can be significantly increased through the use of Kleinsche Fields . According to the researcher, the magnet technology appears to stimulate the cells, which results in increased cell activity. Further studies with larger cell populations are necessary to better understand the long-term effects.
Is the study relevant to everyday life?
Our conclusion of the study
Many diseases are now associated with a malfunction of the mitochondria. Damaged "cellular power plants" can lead to major problems, particularly in areas of the body with high energy requirements such as the muscular or nervous system. Potential areas of application could therefore lie in immunomodulation, cell regeneration and mitochondrial medicine:
The state of health of the "cellular power plants" can reflect the state of health of the entire body. Improving their performance can therefore have a positive effect on all areas of health.
Improved mitochondrial performance - as suggested by the study - can promote the regenerative capacity of cells and thus play an important role in chronic fatigue and ageing.
Mitochondrial health has an impact on numerous diseases, including neurodegenerative diseases such as Alzheimer's, multiple sclerosis and Parkinson's, as well as metabolic syndrome (diabetes, obesity) and cardiovascular diseases.